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KMID : 1004520110270040449
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Journal of Dental Rehabilitation and Applied Science
2011 Volume.27 No. 4 p.449 ~ p.454
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Bisphophonate-Related Osteonecrosis of the Jaw (BRONJ)
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Kim Hyeon-Mook
Park Chan-Jin
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Abstract
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Recently, jawbone osteonecrosis has been largely reported as a potential adverse effect of bisphosphonate (BP)administration. Currently available published incidence data for BRONJ are based on retrospective studies and estimates of cumulative incidence range from 0.8 to 12%. The mandible is more commonly affected than the maxilla (2:1 ratio), and 60-70% of cases are preceded by a dental surgical procedure. The signs and symptoms that may occur before the appearance of clinical evident osteonecrosis include changes in the health of periodontal tissues, non-healing mucosal ulcers, loose teeth and unexplained soft-tissue infection. Tooth extraction as a precipitating event is a common observation. The significant benefits that bisphosphonates offer to patients clearly surpass the risk of potential side effects; however, any patient for whom prolonged bisphosphonate therapy is indicated, should be provided with preventive dental care in order to minimize the risk of developing this severe condition.
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KEYWORD
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bisphosphonate, dental treatment, osteonecrosis, BRONJ
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